Artificial Intelligence (AI) Model: Adaptive Neuro-Fuzzy Inference System (ANFIS) for Diagnosis of COVID-19 Influenza

The COVID-19 influenza became a curse on the world. It has been around for two years, so no one needs to make a big introduction of it. It has became a significant challenge around the world. Owing to this, we made dynamic networks using an amalgamating of fuzzy logic and neural networks for the prediction of sufferers of COVID-19. These hybrid networks serve for the assessment of the COVID-19 victims and usefully serve for the assessment of the medical resources needed for future victims. This manuscript proposed Sugeno Adaptive Neuro-Fuzzy Inference System (SANFIS) prediction model for COVID-19 prediction in Andhra Pradesh, India. We gathered data on positive COVID-19 sufferers in Andhra Pradesh for this purpose. The data can be separated into three categories: training set, testing set and checking set. We have utilized Root Mean Square Deviation (RMSD) for prediction precision. If the prediction model has a lower RMSD value, it is regarded as the best forecast. In this study, we concluded that the 3 Triangular MFns for each input were excellent with the extreme precision for all of the districts based on our expertise. In the end, we deployed seven SANFIS replicas in Andhra Pradesh, but we discovered that SANFIS6 and SANFIS7 provided excellent COVID-19 prediction results. These findings will assist the government, healthcare agencies, and medical organizations in planning for future COVID-19 victims' medical requirements. These sorts of Sugeno Adaptive Neuro-Fuzzy Inference System (SANFIS) prediction models based on Artificial Intelligence (AI) will be beneficial in overcoming the COVID-19

NOVEL ANTICOAGULANTS BEYOND HEPARIN AND WARFARIN

Objective: The objective of the study is to know about newer anticoagulant drugs.Method: The Vitamin K adversaries are the single type of oral anticoagulant in the pharmaceutical, and which is endorsed for long-haul utilize.What is more, the Vitamin K adversaries are exceedingly successful, so it is utilized to avert, and treatment of most thrombotic infections in patients,the noteworthy interpatient and intrapatient are additionally fluctuation in measurement response, and the thin restorative medication record andthe more quantities of medication and dietary communications related with these specialists have lead clinicians, patients, and examiners to scanfor different operators. The three new orally controlled anticoagulants are apixaban, dabigatran, and rivaroxaban, which are in the late periods ofprogression and a couple of others they are basically entering (or traveling through), the earlier times of examinations. Those most recent anticoagulantdrugs are being contemplated just for the avoidance and furthermore the treatment of venous for the thromboembolism, and the treatment of intensecoronary conduit disorders, and furthermore the counteractive action of stroke in patients influenced by atrial fibrillation.Results: The pharmacological action of the three new orally controlled anticoagulants is apixaban, dabigatran, and rivaroxaban completely reviewedand compared with warfarin.Conclusion: We are compared the newer anticoagulant with warfarin and discussed about advantages of newer anticoagulants

ANTI-ATHEROSCLEROTIC ACTIVITY OF ETHANOLIC EXTRACT OF CHRYSANTHEMUM INDICUM L. FLOWERS AGAINST HIGH-FAT DIET-INDUCED ATHEROSCLEROSIS IN MALE WISTAR RATS

  Objective: The aim of the present study was to evaluate the anti-atherosclerotic activity of ethanolic extract of Chrysanthemum indicum (EECI) flowers against high-fat diet induction in male Wistar rats.Methods: The method used for induction of atherosclerosis was high-fat diet for 28 days. Rats were divided into five groups (n=6). Group I served as normal. Group II serves as high-fat diet-treated group. Group III serves as standard treated with high-fat diet+atorvastatin (30 mg/kg, p.o). Group IV serves as low dose treated with high-fat diet+EECI (150 mg/kg, p.o.). Group V serves as high dose treated with high-fat diet+EECI (300 mg/kg, p.o.). The following parameters, glucose, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (TC), very LDL (VLDL), triglycerides (TG), atherogenic index (AI), serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, total protein, food consumption, and body weight, were evaluated and histopathological studies were performed.Results: The results showed that EECI at a dose of 150 mg/kg and 300 mg/kg exhibited significant decrease in glucose, TG, TC, LDL-cholesterol (LDL-C), HDL, VLDL, AI, and total protein levels when compared to high-fat diet group. This investigation reveals that the extract-treated groups lower the serum TC and LDL-C levels significantly, which reduces the risk of coronary heart disease.Conclusion: The experimental studies show that the EECI of both doses 150 mg/kg and 300 mg/kg, respectively, showed significant reduction in lipid profile, glucose, and total protein. From the study, the plant extract showed anti-atherosclerotic activity and thus authenticates its ethnomedicinal use.Â

A 3-axis satellite attitude control using CATCS.

A 3-axis attitude control for a small satellite using combined attitude and thermal control system (CATCS) is presented in this paper. The CATCS system is designed to couple the attitude and the thermal control systems in one system. The CATCS principle is based on the use of the onboard excess heat to circulate a fluid inside a closed duct under the influence of generated current and magnetic flux fields. Till to date, the use of CATCS has been demonstrated for a single axis attitude control of a small satellite. The complete onboard 3-axis attitude control architecture based on the PI-controllers is implemented and numerically tested to enhance the closed-loop attitude control response of a satellite. The simulated attitude performances show that the CATCS system is able to perform the 3-axis attitude control of a satellite

Ethnobotanical studies on medicinal plants used by sugalis of yerramalais in kurnool district, Andhra Pradesh, India

In India, the use of different parts of several medicinal plants to cure specific ailments has been practiced since ancient times. Ehanobotanical studies were carried out to collect information on the use of medicinal plants by the tribal community (Sugalis) who live in the forests of Yerramalais of Kurnool district, Andhra Pradesh, India. The present paper deals with identification of 40 medicinal plants, with local names used by Sugalis for different diseases. The information about different types of medicinal plants used by them for various diseases recorded orally by interviewing the elders, Vaidyas (doctors) of that tribe by visiting their habitats called Thandas. Collected plants are stored in the Departmental Herbarium of Osmania College, Kurnool. Most of the medicinal plants are taken in as roots, tubers, stem and leaves, are taken orally with or without combination of other plants, external applications like paste, fumigation. Most of plants used by them are Herbs (42%), shrubs (20%), Trees (33%).and Climbers (5%) The most striking feature of tribal life is their simplicity. The forest is able to provide them with everything. Professionally they are peasants, food-gatherers, hunters, small farmers, and, nomads. Sugalis use medicinal plants mainly for viral fevers, skin deceases, snake & scorpion bites and stomach problems. It is observed that the urban educated people are more aware of good effects of herbal medicine over allopathic medicine than the rural people. Due to the degraded forests and depleted resources, they are migrating to urban areas for livelihood. So there is a danger of losing knowledge of medicinal plants for human welfare. Hence there is an urgent need to document and popularize the value of herbal medicine among the rural people through Vana Samrakhak Samithi and other agencies.Keywords: Ehanobotany, Sugalis, Thandas, Yerramalais, Easteren ghats

Ethnobotanical studies on medicinal plants used by sugalis of yerramalais in kurnool district, Andhra Pradesh, India

In India, the use of different parts of several medicinal plants to cure specific ailments has been practiced since ancient times. Ehanobotanical studies were carried out to collect information on the use of medicinal plants by the tribal community (Sugalis) who live in the forests of Yerramalais of Kurnool district, Andhra Pradesh, India. The present paper deals with identification of 40 medicinal plants, with local names used by Sugalis for different diseases. The information about different types of medicinal plants used by them for various diseases recorded orally by interviewing the elders, Vaidyas (doctors) of that tribe by visiting their habitats called Thandas. Collected plants are stored in the Departmental Herbarium of Osmania College, Kurnool. Most of the medicinal plants are taken in as roots, tubers, stem and leaves, are taken orally with or without combination of other plants, external applications like paste, fumigation. Most of plants used by them are Herbs (42%), shrubs (20%), Trees (33%).and Climbers (5%) The most striking feature of tribal life is their simplicity. The forest is able to provide them with everything. Professionally they are peasants, food-gatherers, hunters, small farmers, and, nomads. Sugalis use medicinal plants mainly for viral fevers, skin deceases, snake & scorpion bites and stomach problems. It is observed that the urban educated people are more aware of good effects of herbal medicine over allopathic medicine than the rural people. Due to the degraded forests and depleted resources, they are migrating to urban areas for livelihood. So there is a danger of losing knowledge of medicinal plants for human welfare. Hence there is an urgent need to document and popularize the value of herbal medicine among the rural people through Vana Samrakhak Samithi and other agencies.Keywords: Ehanobotany, Sugalis, Thandas, Yerramalais, Easteren ghats

DEVELOPMENT AND VALIDATION OF DAPAGLIFLOZIN BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD AND IT'S FORCED DEGRADATION STUDIES

  Objective: To develop and validate a simple, selective, precise, and accurate method for the estimation of dapagliflozin using reversed-phase high-performance liquid chromatography (RP-HPLC) technique in bulk and tablet formulation.Methods: The proposed method utilizes chromatographic conditions hypersil BDS (250 mm × 4.6 mm, 5 μ), mobile phase was buffer:acetonitrile (60:40) ratio, flow rate was maintained 1 ml/minute, column temperature was set at 30°C, detection wave length was 245 nm, and diluent was mobile phase.Results: By injecting 5 times of the standard solution system suitability parameters were studied, and results were found well under the acceptance criteria. The linearity study was performed by taking 25-150% levels, and the R2 value was found to be 0.999, precision was found to be 0.5 for repeatability and 0.31 for intermediate precision. The % recovery was found to be 99.89%. Limit of detection and limit of quantitation were found to be 0.60 μg/ml and 1.81 μg/ml, respectively. The % purity was found to be 99.71%. Degradation study on dapagliflozin was performed and concluded that the purity threshold was more than purity angle and within the acceptable range.Conclusion: The developed RP-HPLC method for dapagliflozin was found to be simple, precise, accurate, reproducible, and cost effective. Statistical analysis of the developed method conforms that the proposed method is an appropriate and it can be useful for the routine analysis. This method gives the basic idea to the researcher who is working in area such as product development and finish product testing